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Group for Translational EV Research

Extracellular vesicles (EVs), also known as exosomes or microvesicles, mediate intercellular signaling under physiological and pathological conditions and can offer therapeutic benefits depending on their origin [1, 2, 3].

In this context, the group led by Prof. Dr. Bernd Giebel at the Institute of Transfusion Medicine, University Hospital Essen, focuses on unraveling the therapeutic potential of EVs derived from mesenchymal stem/stromal cells (MSCs). Having demonstrated promising therapeutic effects in various models [4, 5, 6, 7], including the successful treatment of a graft-versus-host disease patient [8], the group is now optimizing and standardizing MSC-EV production to meet clinical-grade requirements.

To enhance manufacturing and quality control strategies for EV products, the group is dedicated to developing innovative methods for EV preparation and characterization. Notably, they introduced nanoparticle tracking analysis to the field in 2011 [9] and imaging flow cytometry in 2019 [10].

To advance the EV field, BG served as the founding president of the German Society of Extracellular Vesicles (2017–2023) and currently leads the Exosome Committee of the International Society of Cell and Gene Therapy (ISCT). He is also an active member of the International Society of Extracellular Vesicles (ISEV) and one of the three co-initiators of the Mobility for Vesicles in Europe (MOVE) initiative, a federation of European national EV societies. In collaboration with other experts in the therapeutic EV field, he has coordinated and co-authored several influential white papers on translational EV research [11, 12, 13].

Principal investigator

Prof. Dr.rer.nat.
Bernd Giebel

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PostDoc

Dr.
Tanja Jasmin Kutzner

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Telefon 0201-723-84572

Technicians

Robin Dittrich

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Telefon 0201-723-83039

Sonja Amri

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Telefon 0201-723-4018

PhD Students

Tobias Tertel

Senior researcher and expert in extracellular vesicles for diagnostics and therapy.

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Telefon 0201 723 83032
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Tim Milfeit

Junior researcher with expertise in biochemical engineering and bioprocess development.

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Telefon 0201 723 83552
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Mitarbeiter Platzhalter Bild

Chien Chun (Jeter) Huang

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Telefon 0201 723 83033
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Mohamed Gamal Mohamed Elbeltagy

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Telefon 0201 723 4017

Bachelor/Master Students

Jana Kriebel

Telefon 0201 723 4017
Name: 
Michel Bremer
Florian Murke
Oumaima Stambouli
Shoaib Rao
André Görgens
Stefan Radtke
Anna Ludwig
Simon Staubach
Fabiola Nardi-Bauer
Verena Börger
Anna-Lena Lütticke
Ali Al-Jipouri
Yanis Mouloud

Present research

    Publikationen

    ReferenceImpact Factor
    1. M. Holcar, I. Marić, T. Tertel, K. Goričar, U. Čegovnik Primožič, D. Černe, B. Giebel, M. Lenassi, Comprehensive Phenotyping of Extracellular Vesicles in Plasma of Healthy Humans – Insights Into Cellular Origin and Biological Variation. J Extracell Vesicles, 2025, 14, e70039.16.0
    ReferenceImpact Factor
    1. M. Abuzan, R. Surugiu, C. Wang, A. Mohamud-Yusuf, T. Tertel, B. Catalin, T.R. Doeppner, B. Giebel, D.M. Hermann, A. Popa-Wagner, Extracellular Vesicles Obtained from Hypoxic Mesenchymal Stromal Cells Induce Neurological Recovery, Anti-inflammation, and Brain Remodeling After Distal Middle Cerebral Artery Occlusion in Rats. Transl Stroke Res, 2024.6.422
    2. J. Barekzai, L. Refflinghaus, M. Okpara, L. Tasto, T. Tertel, B. Giebel, P. Czermak, D. Salzig, Process development for the production of mesenchymal stromal cell-derived extracellular vesicles in conventional 2D systems. Cytotherapy, 2024, 26, 999-1012.5.414
    3. N. Hagemann, Y. Qi, A. Mohamud Yusuf, A. Li, A. Squire, T. Tertel, B. Giebel, P. Ludewig, P. Spangenberg, J. Chen, A. Mosig, M. Gunzer, D.M. Hermann, Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy. Arterioscler Thromb Vasc Biol, 2024, 44, 915-929.10.164
    4. D.M. Hermann, B. Giebel, Extracellular vesicles: multiple signaling capabilities and translation into promising therapeutic targets to promote neuronal plasticity. Neural Regen Res, 2024.5.887
    5. D.M. Hermann, L. Peruzzotti-Jametti, B. Giebel, S. Pluchino, Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling. Brain, 2024, 147, 372-389.13.501
    6. Y. Mouloud, S. Staubach, O. Stambouli, S. Mokhtari, T.J. Kutzner, D. Zwanziger, H. Hemeda, B. Giebel, Calcium chloride declotted human platelet lysate promotes the expansion of mesenchymal stromal cells and allows manufacturing of immunomodulatory active extracellular vesicle products. Cytotherapy, 2024, 26, 988-998.5.414
    7. V.V.T. Nguyen, J.A. Welsh, T. Tertel, A. Choo, S.I. van de Wakker, K.A.Y. Defourny, B. Giebel, P. Vader, J. Padmanabhan, S.K. Lim, E.N.M. Nolte-‚t Hoen, M.C. Verhaar, R.B. Bostancioglu, A.M. Zickler, J.M. Hong, J.C. Jones, S. El Andaloussi, B.W.M. van Balkom, A. Görgens, Inter-laboratory multiplex bead-based surface protein profiling of MSC-derived EV preparations identifies MSC-EV surface marker signatures. J Extracell Vesicles, 2024, 13, e12463.16.0
    8. P.N.V. Pham, L. Yahsaly, C. Ochsenfarth, B. Giebel, R. Schnitzler, P. Zahn, U.H. Frey, Influence of Anesthetic Regimes on Extracellular Vesicles following Remote Ischemic Preconditioning in Coronary Artery Disease. Int J Mol Sci, 2024, 25.5.924
    9. J.A. Welsh, D.C.I. Goberdhan, L. O’Driscoll, E.I. Buzas, C. Blenkiron, B. Giebel, et al., Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles, 2024, 13, e12404.16.0
    ReferenceImpact Factor
    1. Alt, M.; Wolf, S.; van de Sand, L.; Dittrich, R.; Tertel, T.; Brochhagen, L.; Dirks, M.; Aufderhorst, U. W.; Thümmler, L.; Otte, M.; Rainer, K.; Dittmer, U.; Giebel, B; Trilling, M.; Silke Heilingloh, C.; Lotfi, R.; Roggendorf, M.; Witzke, O.; Krawczyk, A., Cell-to-cell spread inhibiting antibodies constitute a correlate of protection against herpes simplex virus type 1 reactivations: A retrospective study. Front Immunol 2023, 14, 1143870.8.786
    2. Bauer, F. N.; Tertel, T.; Stambouli, O.; Wang, C.; Dittrich, R.; Staubach, S.; Börger, V.; Hermann, D. M.; Brandau, S.; Giebel, B, CD73 activity of mesenchymal stromal cell-derived extracellular vesicle preparations is detergent-resistant and does not correlate with immunomodulatory capabilities. Cytotherapy 2023, 25 (2), 138-147.5.414
    3. Bremer, M.; Nardi Bauer, F.; Tertel, T.; Dittrich, R.; Horn, P. A.; Börger, V.; Giebel, B, Qualification of a multidonor mixed lymphocyte reaction assay for the functional characterization of immunomodulatory extracellular vesicles. Cytotherapy 2023, 25 (8), 847-857.5.414
    4. Dekevic, G.; Tertel, T.; Tasto, L.; Schmidt, D.; Giebel, B; Czermak, P.; Salzig, D., A Bioreactor-Based Yellow Fever Virus-like Particle Production Process with Integrated Process Analytical Technology Based on Transient Transfection. Viruses 2023, 15 (10).5.818
    5. Heidegger, S.; Stritzke, F.; Dahl, S.; Daßler-Plenker, J.; Joachim, L.; Buschmann, D.; Fan, K.; Sauer, C. M.; Ludwig, N.; Winter, C.; Enssle, S.; Li, S.; Perl, M.; Görgens, A.; Haas, T.; Orberg, E. T.; Göttert, S.; Wölfel, C.; Engleitner, T.; Cortés-Ciriano, I.; Rad, R.; Herr, W.; Giebel, B; Ruland, J.; Bassermann, F.; Coch, C.; Hartmann, G.; Poeck, H., Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy. Cell Rep Med 2023, 4 (9), 101171.8.8
    6. Janev, A.; Banerjee, A.; Weidinger, A.; Dimec, J.; Leskošek, B.; Silini, A. R.; Cirman, T.; Wolbank, S.; Ramuta, T.; Jerman, U. D.; Pandolfi, A.; Di Pietro, R.; Pozzobon, M.; Giebel, B; Eissner, G.; Ferk, P.; Lang-Olip, I.; Alviano, F.; Soritau, O.; Parolini, O.; Kreft, M. E., Recommendations from the COST action CA17116 (SPRINT) for the standardization of perinatal derivative preparation and in vitro testing. Front Bioeng Biotechnol 2023, 11, 1258753.5.89
    7. Karantanou, C.; Minciacchi, V. R.; Kumar, R.; Zanetti, C.; Bravo, J.; Pereira, R. S.; Tascher, G.; Tertel, T.; Covarrubias-Pinto, A.; Bankov, K.; Pfeffermann, L. M.; Bonig, H.; Divieti-Pajevic, P.; McEwan, D. G.; Giebel, B; Münch, C.; Dikic, I.; Krause, D. S., Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression. Blood Adv 2023, 7 (7), 1190-1203.7.637
    8. Labusek, N.; Ghari, P.; Mouloud, Y.; Köster, C.; Diesterbeck, E.; Hadamitzky, M.; Felderhoff-Müser, U.; Bendix, I.; Giebel, B; Herz, J., Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury. J Neuroinflammation 2023, 20 (1), 280.9.3
    9. Labusek, N.; Mouloud, Y.; Köster, C.; Diesterbeck, E.; Tertel, T.; Wiek, C.; Hanenberg, H.; Horn, P. A.; Felderhoff-Müser, U.; Bendix, I.; Giebel, B; Herz, J., Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury. Inflamm Regen 2023, 43 (1), 24.5.0
    10. Madel, R. J.; Börger, V.; Dittrich, R.; Bremer, M.; Tertel, T.; Phuong, N. N. T.; Baba, H. A.; Kordelas, L.; Staubach, S.; Stein, F.; Haberkant, P.; Hackl, M.; Grillari, R.; Grillari, J.; Buer, J.; Horn, P. A.; Westendorf, A. M.; Brandau, S.; Kirschning, C. J.; Giebel, B, Independent human mesenchymal stromal cell-derived extracellular vesicle preparations differentially attenuate symptoms in an advanced murine graft-versus-host disease model. Cytotherapy 2023, 25 (8), 821-836.5.414
    11. Ossendorff, R.; Grad, S.; Tertel, T.; Wirtz, D. C.; Giebel, B; Börger, V.; Schildberg, F. A., Immunomodulatory potential of mesenchymal stromal cell-derived extracellular vesicles in chondrocyte inflammation. Front Immunol 2023, 14, 1198198.8.786
    12. Riehl, D. R.; Sharma, A.; Roewe, J.; Murke, F.; Ruppert, C.; Eming, S. A.; Bopp, T.; Kleinert, H.; Radsak, M. P.; Colucci, G.; Subramaniam, S.; Reinhardt, C.; Giebel, B; Prinz, I.; Guenther, A.; Strand, D.; Gunzer, M.; Waisman, A.; Ward, P. A.; Ruf, W.; Schäfer, K.; Bosmann, M., Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27. Proc Natl Acad Sci U S A 2023, 120 (40), e2215421120.12.779
    13. Sharar, N.; Wüstefeld, K.; Talukder, R. M.; Skolnik, J.; Kaufmann, K.; Giebel, B; Börger, V.; Nolte, F.; Watzl, C.; Weichert, F.; Hergenröder, R.; Shpacovitch, V., The Employment of the Surface Plasmon Resonance (SPR) Microscopy Sensor for the Detection of Individual Extracellular Vesicles and Non-Biological Nanoparticles. Biosensors (Basel) 2023, 13 (4).5.743
    14. Shekari, F.; Alibhai, F. J.; Baharvand, H.; Börger, V.; Bruno, S.; Davies, O.; Giebel, B; Gimona, M.; Salekdeh, G. H.; Martin-Jaular, L.; Mathivanan, S.; Nelissen, I.; Nolte-‚t Hoen, E.; O’Driscoll, L.; Perut, F.; Pluchino, S.; Pocsfalvi, G.; Salomon, C.; Soekmadji, C.; Staubach, S.; Torrecilhas, A. C.; Shelke, G. V.; Tertel, T.; Zhu, D.; Théry, C.; Witwer, K.; Nieuwland, R., Cell culture-derived extracellular vesicles: Considerations for reporting cell culturing parameters. J Extracell Biol 2023, 2 (10), e115.
    15. Tertel, T.; Dittrich, R.; Arsène, P.; Jensen, A.; Giebel, B, EV products obtained from iPSC-derived MSCs show batch-to-batch variations in their ability to modulate allogeneic immune responses in vitro. Front Cell Dev Biol 2023, 11, 1282860.6.081
    16. Toh, W. S.; Yarani, R.; El Andaloussi, S.; Cho, B. S.; Choi, C.; Corteling, R.; De Fougerolles, A.; Gimona, M.; Herz, J.; Khoury, M.; Robbins, P. D.; Williams, D.; Weiss, D. J.; Rohde, E.; Giebel, B; Lim, S. K., A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, „Therapeutic advances with native and engineered human extracellular vesicles“. Cytotherapy 2023, 25 (8), 810-814.5.414
    17. Trivanovic, D.; Volkmann, N.; Stoeckl, M.; Tertel, T.; Rudert, M.; Giebel, B; Herrmann, M., Enhancement of Immunosuppressive Activity of Mesenchymal Stromal Cells by Platelet-Derived Factors is Accompanied by Apoptotic Priming. Stem Cell Rev Rep 2023, 19 (3), 713-733.6.084
    18. Tsiapalis, D.; Floudas, A.; Tertel, T.; Boerger, V.; Giebel, B; Veale, D. J.; Fearon, U.; O’Driscoll, L., Therapeutic Effects of Mesenchymal/Stromal Stem Cells and Their Derived Extracellular Vesicles in Rheumatoid Arthritis. Stem Cells Transl Med 2023, 12 (12), 849-862.7.384
    19. van Royen, M. E.; Soekmadji, C.; Grange, C.; Webber, J. P.; Tertel, T.; Droste, M.; Buescher, A.; Giebel, B; Jenster, G. W.; Llorente, A.; Blijdorp, C. J.; Burger, D.; Erdbrügger, U.; Martens-Uzunova, E. S., The quick reference card „Storage of urinary EVs“ – A practical guideline tool for research and clinical laboratories. J Extracell Vesicles 2023, 12 (3), e12286.16.0
    20. Wang, B.; Wöhler, A.; Greven, J.; Salzmann, R. J. S.; Keller, C. M.; Tertel, T.; Zhao, Q.; Mert, Ü.; Horst, K.; Lupu, L.; Huber-Lang, M.; van Griensven, M.; Mollnes, T. E.; Schaaf, S.; Schwab, R.; Strassburg, C. P.; Schmidt-Wolf, I. G. H.; Giebel, B; Hildebrand, F.; Lukacs-Kornek, V.; Willms, A. G.; Kornek, M. T., Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma. Front Immunol 2023, 14, 1279496.8.786
    21. Yin, D.; Wang, C.; Qi, Y.; Wang, Y. C.; Hagemann, N.; Mohamud Yusuf, A.; Dzyubenko, E.; Kaltwasser, B.; Tertel, T.; Giebel, B; Gunzer, M.; Popa-Wagner, A.; Doeppner, T. R.; Hermann, D. M., Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages. J Neuroinflammation 2023, 20 (1), 210.9.3
    22. Welsh, J. A.; Arkesteijn, G. J. A.; Bremer, M.; Cimorelli, M.; Dignat-George, F.; Giebel, B; Görgens, A.; Hendrix, A.; Kuiper, M.; Lacroix, R.; Lannigan, J.; van Leeuwen, T. G.; Lozano-Andrés, E.; Rao, S.; Robert, S.; de Rond, L.; Tang, V. A.; Tertel, T.; Yan, X.; Wauben, M. H. M.; Nolan, J. P.; Jones, J. C.; Nieuwland, R.; van der Pol, E., A compendium of single extracellular vesicle flow cytometry. J Extracell Vesicles 2023, 12 (2), e12299.16.0
    23. Yarani, R.; Lim, S. K.; Giebel, B, Mesenchymal stromal cells extracellular vesicles; unlocking the potential. Cytotherapy 2023, 25 (8), 808-809.5.414
    24. Shekari, F.; Alibhai, F. J.; Baharvand, H.; Börger, V.; Bruno, S.; Davies, O.; Giebel, B; Gimona, M.; Salekdeh, G. H.; Martin-Jaular, L.; Mathivanan, S.; Nelissen, I.; Nolte-‚t Hoen, E.; O’Driscoll, L.; Perut, F.; Pluchino, S.; Pocsfalvi, G.; Salomon, C.; Soekmadji, C.; Staubach, S.; Torrecilhas, A. C.; Shelke, G. V.; Tertel, T.; Zhu, D.; Théry, C.; Witwer, K.; Nieuwland, R., Considerations for Reporting EV-Based Experiments. J Extracell Biol 2023, 2 (10), e115.
    25. Yin, D.; Wang, C.; Qi, Y.; Wang, Y. C.; Hagemann, N.; Mohamud Yusuf, A.; Dzyubenko, E.; Kaltwasser, B.; Tertel, T.; Giebel, B; Gunzer, M.; Popa-Wagner, A.; Doeppner, T. R.; Hermann, D. M., Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages. J Neuroinflammation 2023, 20 (1), 210.9.3
    26. Wang, B.; Wöhler, A.; Greven, J.; Salzmann, R. J. S.; Keller, C. M.; Tertel, T.; Zhao, Q.; Mert, Ü.; Horst, K.; Lupu, L.; Huber-Lang, M.; van Griensven, M.; Mollnes, T. E.; Schaaf, S.; Schwab, R.; Strassburg, C. P.; Schmidt-Wolf, I. G. H.; Giebel, B; Hildebrand, F.; Lukacs-Kornek, V.; Willms, A. G.; Kornek, M. T., Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma. Front Immunol 2023, 14, 1279496.8.786
    ReferenceImpact Factor
    1. Breitwieser, K.; Koch, L. F.; Tertel, T.; Proestler, E.; Burgers, L. D.; Lipps, C.; Adjaye, J.; Fürst, R.; Giebel, B; Saul, M. J., Detailed Characterization of Small Extracellular Vesicles from Different Cell Types Based on Tetraspanin Composition by ExoView R100 Platform. Int J Mol Sci 2022, 23 (15).5.6
    2. Demais, V.; Pohl, A.; Wunderlich, K. A.; Pfaller, A. M.; Kaplan, L.; Barthélémy, A.; Dittrich, R.; Puig, B.; Giebel, B; Hauck, S. M.; Pfrieger, F. W.; Grosche, A., Release of VAMP5-positive extracellular vesicles by retinal Müller glia in vivo. J Extracell Vesicles 2022, 11 (9), e12254.16.0
    3. Dumbrava, D. A.; Surugiu, R.; Börger, V.; Ruscu, M.; Tertel, T.; Giebel, B; Hermann, D. M.; Popa-Wagner, A., Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats. Geroscience 2022, 44 (1), 293-310.7.7
    4. Flores, A. I.; Pipino, C.; Jerman, U. D.; Liarte, S.; Gindraux, F.; Kreft, M. E.; Nicolas, F. J.; Pandolfi, A.; Tratnjek, L.; Giebel, B; Pozzobon, M.; Silini, A. R.; Parolini, O.; Eissner, G.; Lang-Olip, I., Perinatal derivatives: How to best characterize their multimodal functions in vitro. Part C: Inflammation, angiogenesis, and wound healing. Front Bioeng Biotechnol 2022, 10, 965006.5.9
    5. Hermann, D. M.; Xin, W.; Bähr, M.; Giebel, B; Doeppner, T. R., Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke. Theranostics 2022, 12 (13), 5776-5802.11.6
    6. Jablonska, J.; Rist, M.; Spyra, I.; Tengler, L.; Domnich, M.; Kansy, B.; Giebel, B; Thakur, B. K.; Rotter, N.; Lang, S.; Ludwig, S., Evaluation of Immunoregulatory Biomarkers on Plasma Small Extracellular Vesicles for Disease Progression and Early Therapeutic Response in Head and Neck Cancer. Cells 2022, 11 (5).7.6
    7. Jennrich, S.; Pelzer, M.; Tertel, T.; Koska, B.; Vüllings, M.; Thakur, B. K.; Jendrossek, V.; Timmermann, B.; Giebel, B; Rudner, J., CD9- and CD81-positive extracellular vesicles provide a marker to monitor glioblastoma cell response to photon-based and proton-based radiotherapy. Front Oncol 2022, 12, 947439.6.2
    8. Lang, J. B.; Buck, M. C.; Rivière, J.; Stambouli, O.; Sachenbacher, K.; Choudhary, P.; Dietz, H.; Giebel, B; Bassermann, F.; Oostendorp, R. A. J.; Götze, K. S.; Hecker, J. S., Comparative analysis of extracellular vesicle isolation methods from human AML bone marrow cells and AML cell lines. Front Oncol 2022, 12, 949261.6.2
    9. Mohamud Yusuf, A.; Hagemann, N.; Zhang, X.; Zafar, M.; Hussner, T.; Bromkamp, C.; Martiny, C.; Tertel, T.; Börger, V.; Schumacher, F.; Solari, F. A.; Hasenberg, M.; Kleinschnitz, C.; Doeppner, T. R.; Kleuser, B.; Sickmann, A.; Gunzer, M.; Giebel, B; Kolesnick, R.; Gulbins, E.; Hermann, D. M., Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles. Basic Res Cardiol 2022, 117 (1), 43.17.2
    10. Papait, A.; Silini, A. R.; Gazouli, M.; Malvicini, R.; Muraca, M.; O’Driscoll, L.; Pacienza, N.; Toh, W. S.; Yannarelli, G.; Ponsaerts, P.; Parolini, O.; Eissner, G.; Pozzobon, M.; Lim, S. K.; Giebel, B, Perinatal derivatives: How to best validate their immunomodulatory functions. Front Bioeng Biotechnol 2022, 10, 981061.5.9
    11. Pozzobon, M.; D’Agostino, S.; Roubelakis, M. G.; Cargnoni, A.; Gramignoli, R.; Wolbank, S.; Gindraux, F.; Bollini, S.; Kerdjoudj, H.; Fenelon, M.; Di Pietro, R.; Basile, M.; Borutinskaitė, V.; Piva, R.; Schoeberlein, A.; Eissner, G.; Giebel, B; Ponsaerts, P., General consensus on multimodal functions and validation analysis of perinatal derivatives for regenerative medicine applications. Front Bioeng Biotechnol 2022, 10, 961987.6.8
    12. Preußer, C.; Stelter, K.; Tertel, T.; Linder, M.; Helmprobst, F.; Szymanski, W.; Graumann, J.; Giebel, B; Reinartz, S.; Müller, R.; Weber, G.; von Strandmann, E. P., Isolation of native EVs from primary biofluids-Free-flow electrophoresis as a novel approach to purify ascites-derived EVs. J Extracell Biol 2022, 1 (12), e71.
    13. Ramos, Y. F. M.; Tertel, T.; Shaw, G.; Staubach, S.; de Almeida, R. C.; Suchiman, E.; Kuipers, T. B.; Mei, H.; Barry, F.; Murphy, M.; Giebel, B; Meulenbelt, I., Characterizing the secretome of licensed hiPSC-derived MSCs. Stem Cell Res Ther 2022, 13 (1), 434.6.8
    14. Silini, A. R.; Ramuta, T.; Pires, A. S.; Banerjee, A.; Dubus, M.; Gindraux, F.; Kerdjoudj, H.; Maciulatis, J.; Weidinger, A.; Wolbank, S.; Eissner, G.; Giebel, B; Pozzobon, M.; Parolini, O.; Kreft, M. E., Methods and criteria for validating the multimodal functions of perinatal derivatives when used in oncological and antimicrobial applications. Front Bioeng Biotechnol 2022, 10, 958669.5.9
    15. Staubach, S.; Tertel, T.; Walkenfort, B.; Buschmann, D.; Pfaffl, M. W.; Weber, G.; Giebel, B, Free flow electrophoresis allows quick and reproducible preparation of extracellular vesicles from conditioned cell culture media. Extracell Vesicles Circ Nucl Acids 2022, 3 (1), 31-48.5.6
    16. Tertel, T.; Schoppet, M.; Stambouli, O.; Al-Jipouri, A.; James, P. F.; Giebel, B, Imaging flow cytometry challenges the usefulness of classically used extracellular vesicle labeling dyes and qualifies the novel dye Exoria for the labeling of mesenchymal stromal cell-extracellular vesicle preparations. Cytotherapy 2022, 24 (6), 619-628.5.4
    17. Tertel, T.; Tomić, S.; Đokić, J.; Radojević, D.; Stevanović, D.; Ilić, N.; Giebel, B; Kosanović, M., Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patients. J Extracell Vesicles 2022, 11 (8), e12257.16.0
    18. Wang, C.; Börger, V.; Mohamud Yusuf, A.; Tertel, T.; Stambouli, O.; Murke, F.; Freund, N.; Kleinschnitz, C.; Herz, J.; Gunzer, M.; Popa-Wagner, A.; Doeppner, T. R.; Giebel, B; Hermann, D. M., Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice. Stroke 2022, 53 (1), e14-e18.7.9
    19. Bauer, F. N.; Tertel, T.; Stambouli, O.; Wang, C.; Dittrich, R.; Staubach, S.; Börger, V.; Hermann, D. M.; Brandau, S.; Giebel, B, CD73 activity of mesenchymal stromal cell-derived extracellular vesicle preparations is detergent-resistant and does not correlate with immunomodulatory capabilities. Cytotherapy 2023, 25 (2), 138-147.5.4
    20. Trivanovic, D.; Volkmann, N.; Stoeckl, M.; Tertel, T.; Rudert, M.; Giebel, B; Herrmann, M., Enhancement of Immunosuppressive Activity of Mesenchymal Stromal Cells by Platelet-Derived Factors is Accompanied by Apoptotic Priming. Stem Cell Rev Rep 2023, 19 (3), 713-733.6.7
    ReferenceImpact Factor
    1. Krämer-Albers EM, Pogge von Strandmann E, Fuhrmann G, Nazarenko I, Giebel B, Pfaffl MW. Meeting report of the 4th autumn meeting of the German Society of Extracellular Vesicles (GSEV): cutting edge EV research driven by young scientists. Extracell Vesicles Circ Nucleic Acids. 2021; 2:238-51. 
    2. Wang C, Börger V, Mohamud Yusuf A, Tertel T, Stambouli O, Murke F, Freund N, Kleinschnitz C, Herz J, Gunzer M, Popa-Wagner A, Doeppner TR, Giebel B, Hermann DM. Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice. Stroke. 2021 Dec 1; STROKEAHA121035821.7.9
    3. Nardi Bauer F, Giebel B. CHAPTER 1: Therapeutic Potential of Mesenchymal Stromal Cell-derived Small Extracellular Vesicles. In: Extracellular Vesicles: Applications to Regenerative Medicine, Therapeutics and Diagnostics. 2021; 1-21. 
    4. Van Hoecke L, Van Cauwenberghe C, Börger V, Bruggeman A, Castelein J, Van Imschoot G, Van Wonterghem E, Dittrich R, Claeys W, Xie J, Giebel B, Vandenbroucke RE. Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann–Pick Type C Disease. Biomedicines. 2021; 9(12):1864.6.1
    5. Dumbrava DA, Surugiu R, Börger V, Ruscu M, Tertel T, Giebel B, Hermann DM, Popa-Wagner A. Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats. Geroscience. 2021 Nov 10.7.7
    6. Kordelas L, Buttkereit U, Heinemann FM, Horn PA, Giebel B, Beelen DW, Reinhardt HC, Rebmann V. Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival. Front Immunol. 2021 Sep 24; 12:694843.7.6
    7. Budeus B, Kibler A, Brauser M, Homp E, Bronischewski K, Ross JA, Görgens A, Weniger MA, Dunst J, Kreslavsky T, Vitoriano da Conceição Castro S, Murke F, Oakes CC, Rusch P, Andrikos D, Kern P, Köninger A, Lindemann M, Johansson P, Hansen W, Lundell AC, Rudin A, Dürig J, Giebel B, Hoffmann D, Küppers R, Seifert M. Human cord blood B cells differ from the adult counterpart by conserved Ig repertoires and accelerated response dynamics. J Immunol. 2021 Jun 11; ji2100113.5.4
    8. Hermann DM, Doeppner TR, Giebel B. Circulating MicroRNAs: Posttranscriptional Regulators and Disease Markers Holding Promise in Stroke Prediction. Stroke. 2021 Mar;52(3):954-956.7.9
    9. Rankin-Turner S, Vader P, O’Driscoll L, Giebel B, Heaney LM, Davies OG. A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos. Adv Drug Deliv Rev. 2021 Jun;173:479-491.15.5
    10. Gimona M, Brizzi MF, Choo ABH, Dominici M, Davidson SM, Grillari J, Hermann DM, Hill AF, de Kleijn D, Lai RC, Lai CP, Lim R, Monguió-Tortajada M, Muraca M, Ochiya T, Ortiz LA, Toh WS, Yi YW, Witwer KW, Giebel B, Lim SK. Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles. Cytotherapy. 2021 May;23(5):373-380.5.4
    11. Abel F, Giebel B, Frey UH. Agony of choice: How anesthetics affect the composition and function of extracellular vesicles. Adv Drug Deliv Rev. 2021 Aug;175:113813.15.5
    12. Gregorius J, Wang C, Stambouli O, Hussner T, Qi Y, Tertel T, Börger V, Mohamud Yusuf A, Hagemann N, Yin D, Dittrich R, Mouloud Y, Mairinger FD, Magraoui FE, Popa-Wagner A, Kleinschnitz C, Doeppner TR, Gunzer M, Meyer HE, Giebel B, Hermann DM. Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice. Basic Res Cardiol. 2021 Jun 8;116(1):40.17.2
    13. Budeus B, Kibler A, Brauser M, Homp E, Bronischewski K, Ross JA, Görgens A, Weniger MA, Dunst J, Kreslavsky T, Vitoriano da Conceição Castro S, Murke F, Oakes CC, Rusch P, Andrikos D, Kern P, Köninger A, Lindemann M, Johansson P, Hansen W, Lundell AC, Rudin A, Dürig J, Giebel B, Hoffmann D, Küppers R, Seifert M. Human Cord Blood B Cells Differ from the Adult Counterpart by Conserved Ig Repertoires and Accelerated Response Dynamics. J Immunol. 2021 Jun 11;ji2100113.5.4
    14. Ianni A, Hofmann M, Kumari P, Tarighi S, Al-Tamari HM, Görgens A, Giebel B, Nolte H, Krüger M, Salwig I, Pullamsetti SS, Günther A, Schneider A, Braun T. Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway. Front Cell Dev Biol. 2021 May 26;9:639162.5.2
    15. Hermann DM, Doeppner TR, Giebel B. New Light on the Horizon: Extracellular Vesicles as Diagnostic Tool in Transient Ischemic Attack and Ischemic Stroke. Stroke. 2021 Aug 4;STROKEAHA121036150.7.9
    16. Staubach S, Nardi Bauer F, Tertel T, Börger V, Stambouli O, Salzig D, Giebel B. Scaled preparation of extracellular vesicles from conditioned media. Adv Drug Deliv Rev. 2021 Aug 19;113940. PDF15.5
    ReferenceImpact Factor
    1. Kordelas L, Görgens A, Radtke S, Horn PA, Beelen DW, Giebel B. Allogeneic transplantation of peripheral blood stem cell grafts results in a massive decrease of primitive hematopoietic progenitor frequencies in reconstituted bone marrows. Bone Marrow Transplant 55, 100–109 (2020).4.6
    2. Viol L, Hata S, Pastor-Peidro A, Neuner A, Murke F, Wuchter P, Ho AD, Giebel B, Pereira G. Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis. J Cell Biol. 2020. 219 (3): e201907136.8.8
    3. Dampmann M, Görgens A, Möllmann M, Murke F, Dührsen U, Giebel B, Dürig J. CpG stimulation of chronic lymphocytic leukemia cells induces a polarized cell shape and promotes migration in vitro and in vivo. PLoS One. 2020 Feb 10;15(2):e0228674. doi: 10.1371/journal.pone.0228674. eCollection 2020.2.7
    4. André Görgens, Bernd Giebel. Extracellular Vesicles, Essential Current Concepts in Stem Cell Biology. 219-229. 
    5. Kontopoulou E, Strachan S, Reinhardt K, Kunz F, Walter C, Walkenfort B, Jastrow H, Hasenberg M, Giebel B, von Neuhoff N, Reinhardt D, Kumar Thakur B. Evaluation of dsDNA from extracellular vesicles (EVs) in pediatric AML diagnostics Annals of Hematology. 1–17.2.8
    6. Welsh JA, Van Der Pol E, Ger J.A. Arkesteijn, Bremer M, Brisson A, Coumans F, Dignat-George F, Duggan E, Ghiran I, Giebel B, Görgens A, Hendrix A, Lacroix R, Lannigan J, Sten F.W.M. Libregts, Lozano-Andrés E, Morales-Kastresana A, Robert S, De Rond L, Tertel T, Tigges J, De Wever O, Yan X, Nieuwland R, Marca H.M. Wauben, Nolan JP, Jones JC. MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments Journal of Extracellular Vesicles Volume 9, 2020 – Issue 1.11.0
    7. Chen Wang, Verena Börger, Maryam Sardari, Florian Murke, Jelena Skuljec, Refik Pul, Nina Hagemann, Egor Dzyubenko, Robin Dittrich, Jonas Gregorius, Mike Hasenberg, Christoph Kleinschnitz, Aurel Popa-Wagner, Thorsten R. Doeppner, Matthias Gunzer, Bernd Giebel, Dirk M. Hermann. Mesenchymal Stromal Cell–Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils Stroke. 2020 Apr 26.0
    8. Viktoriya Sokolova, Goodwell Nzou, Selina B. van der Meer, Tatjana Ruks, Marc Heggen, Kateryna Loza, Nina Hagemann, Florian Murke, Bernd Giebel, Dirk M. Hermann, Anthony J. Atala, Matthias Epple. Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model Acta Biomater. 2020 May 12;S1742-7061(20)30220-86.6
    9. Verena Borger, Daniel J. Weiss, Johnathon D. Anderson, Francesc E. Borras, Benedetta Bussolati, David R.F. Carter, Massimo Dominici, Juan M. Falcon-Perez , Mario Gimona, Andrew F. Hill, Andrew M. Hoffman, Dominique de Kleijn, Bruce L. Levine, Rebecca Lim, Jan Lotvall , S. Alex Mitsialis, Marta Monguio-Tortajada, Maurizio Muraca, Rienk Nieuwland, Anna Nowocin, Lorraine O’Driscoll, Luis A. Ortiz, Donald G Phinney, Ilona Reischl, Eva Rohde, Ralf Sanzenbacher, Clotilde Thery, Wei Seong Toh, Kenneth W. Witwer, Sai Kiang Lim, Bernd Giebel. ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19, Cytotherapy (2020).4.3
    10. Tobias Tertel, Michel Bremer, Cecile Maire, Katrin Lamszus, Sven Peine, Rim Jawad, Samir E.L. Andaloussi, Bernd Giebel, Franz L. Ricklefs, André Görgens. High‐Resolution Imaging Flow Cytometry Reveals Impact of Incubation Temperature on Labeling of Extracellular Vesicles with Antibodies Cytometry Part A. 20203.4
    11. Sai Kiang Lim, Bernd Giebel, Daniel J. Weiss, Kenneth W. Witwer, and Eva Rohde. Re: “Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19” by Sengupta et al. Stem Cells and Development 2020, ahead of print3.1
    12. Verena Börger, Simon Staubach, Robin Dittrich, Oumaima Stambouli, Bernd Giebel. “Scaled Isolation of Mesenchymal Stem/Stromal Cell‐Derived Extracellular Vesicles. Current Protocols in Stem Cell Biology, Dec. 2020, Volume 55, Issue 11.0
    13. Hack T, Bertram S, Blair H, Börger V, Büsche G, Denson L, Fruth E, Giebel B, Heidenreich O, Klein-Hitpass L, Kollipara L, Sendker S, Sickmann A, Walter C, von Neuhoff N, Hanenberg H, Reinhardt D, Schneider M, Rasche M. “Exposure of Patient-Derived Mesenchymal Stromal Cells to TGFB1 Supports Fibrosis Induction in a Pediatric Acute Megakaryoblastic Leukemia Model. Mol Cancer Res. 2020 Oct;18(10):1603-1612.5.9
    14. Chen Y, Hoffmeister LM, Zaun Y, Arnold L, Schmid KW, Giebel B, Klein-Hitpass L, Hanenberg H, Squire A, Reinhardt HC, Dührsen U, Bertram S, Hanoun M. “Acute myeloid leukemia-induced remodeling of the human bone marrow niche predicts clinical outcome. Blood Adv. 2020 Oct 27;4(20):5257-5268.4.9
    15. Weiss DJ, Lim SK, Rohde E, Witwer KW, Giebel B. “Weiss Response to Sengupta et al. (DOI: 10.1089/scd.2020.0095). Stem Cells Dev. 2020 Dec;29(24):1533-1534.3.3
    16. Kaminski N, Köster C, Mouloud Y, Börger V, Felderhoff-Müser U, Bendix I, Giebel B, Herz J. “Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain Injury. Front Cell Neurosci. 2020 Dec 10;14:601176.4.6
    17. Silini AR, Di Pietro R, Lang-Olip I, Alviano F, Banerjee A, Basile M, Borutinskaite V, Eissner G, Gellhaus A, Giebel B, Huang YC, Janev A, Kreft ME, Kupper N, Abadía-Molina AC, Olivares EG, Pandolfi A, Papait A, Pozzobon M, Ruiz-Ruiz C, Soritau O, Susman S, Szukiewicz D, Weidinger A, Wolbank S, Huppertz B, Parolini O. “Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature. Front Bioeng Biotechnol. 2020 Dec 17;8:610544.5.5
    18. Tertel T, Görgens A, Giebel B. “Analysis of individual extracellular vesicles by imaging flow cytometry. Methods Enzymol. 2020;645:55-78.1.4
    ReferenceImpact Factor
    1. Gussenhoven R, Klein L, Ophelders D, Habets D, Giebel B, Kramer BW, Schurgers LJ, Reutelingsperger C, Wolfs T Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy. J. Clin. Med. 2019, 8(2), 137; doi: 10.3390/jcm8020137 PMID: 306827875.6
    2. van Balkom BW, Gremmels H, Giebel B, Lim SK. Proteomic signature of mesenchymal stromal cell-derived small extracellular vesicles. Proteomics. 2018 Nov 23:e1800163. doi: 10.1002/pmic.201800163. PMID: 304679893.1
    3. Ricklefs FL, Maire CL, Reimer R, DührsenL, Kolbe K, Holz M, Schneider E, Rissiek A, Babayan A, Hille C, Pantel K, Krasemann S, Glatzel, Heiland DH, Flitsch J, Martens T, Schmidt NO, Peine S, Breakefield XO, Lawler S, Chiocca EA, Fehse B, Giebel B, Görgens A, Westphal M, Lamszus K. Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours. Journal of Extracellular Vesicles, 8:1, 1588555, DOI: 10.1080/20013078.2019.158855511.0
    4. Görgens A, Bremer M, Ferrer-Tur R, Murke F, Tertel T, Horn PA, Thalmann S, Welsh JA, Probst, Guerin C, Boulanger CM, Jones JC, Hanenberg H, Erdbrügger U, Lannigan J, Ricklefs FL, El-Andaloussi S, Giebel B. Optimisation of imaging flow cytometry forthe analysis of single extracellular vesicles byusing fluorescence-tagged vesicles as biologicalreference material. Journal of Extracellular Vesicles, 8:1, 1587567, DOI:10.1080/20013078.2019.158756711.0
    5. Witwer KW, Van Balkom BWM, Bruno S, Choo A, Dominici M, Gimona M, Hill AF, De Kleijn D, Koh M, Lai RC, Mitsialis SA, Ortiz LA, Rohde E, Asada T, Toh WS, Weiss DJ, Zheng L, Giebel B, Lim SK. Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. Journal of Extracellular Vesicles, 2019 Apr 29, 8(1): 1609206, DOI:10.1080/20013078.2019.160920611.0
    6. Kordelas L, Schwich E, Dittrich R, Horn PA, Beelen DW, Börger V, Giebel B, Rebmann V. Individual Immune-Modulatory Capabilities of MSC-Derived Extracellular Vesicle (EV) Preparations and Recipient-Dependent Responsiveness.Int. J. Mol. Sci. 2019, 20(7), 1642; https://doi.org/10.3390/ijms200716424.1
    7. Kopp M, Aufderhorst UW, Alt M, Dittmer U, Eis-Hübinger A, Giebel B, Roggendorf M, Epple M, Krawczyk A. Induction of herpes simplex virus type 1 cell-to-cell spread inhibiting antibodies by a calcium phosphate nanoparticle-based vaccine. Nanomedicine. 2019 Feb;16:138-148. doi: 10.1016/j.nano.2018.12.002.4.7
    8. Frey UH, Klaassen M, Ochsenfarth C, Murke F, Thielmann M, Kottenberg E, Kleinbongard P, Klenke S, Engler A, Heusch G, Giebel B, Peters J. Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro‐RNA signature in CABG patients. Acta Anaesthesiol Scand. 2019 Apr;63(4):483-492. doi: 10.1111/aas.132962.2
    9. Giebel B, Hermann DM. Identification of the right cell sources for the production of therapeutically active extracellular vesicles in ischemic stroke. Ann Transl Med. 2019 May; 7(9): 188.3.6
    10. Sody S, Uddin M, Grüneboom A, Görgens A, Giebel B, Gunzer M, Brandau S. Distinct spatio-temporal dynamics of tumor-associated neutrophils in small tumor lesions. Front Immunol. 2019 Jun 25; 10: 1419.4.7
    11. Radtke S, Görgens A, da Conceição Castro SV, Kordelas L, Köninger A, Dürig J, Möllmann M, Horn PA, Giebel B. Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice. Sci Rep. 2019 Sep 9; 9(1): 12914.4.0
    12. Ricklefs FL, Maire CL, Reimer R, Dührsen L, Kolbe K, Holz M, Schneider E, Rissiek A, Babayan A, Hille C, Pantel K, Krasemann S, Glatzel M, Heiland DH, Flitsch J, Martens T, Schmidt NO, Peine S, Breakefield XO, Lawler S, Chiocca EA, Fehse B, Giebel B, Görgens A, Westphal M, Lamszus K. Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours. J Extracell Vesicles. 2019 Mar 21; 8(1): 1588555.11.0
    13. Görgens A, Bremer M, Ferrer-Tur R, Murke F, Tertel T, Horn PA, Thalmann S, Welsh JA, Probst C, Guerin C, Boulanger CM, Jones JC, Hanenberg H, Erdbrügger U, Lannigan J, Ricklefs FL, El-Andaloussi S, Giebel B. Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles by using fluorescence-tagged vesicles as biological reference material. J Extracell Vesicles. 2019 Mar 21; 8(1): 1587567.11.0
    ReferenceImpact Factor
    1. Thivakaran A, Botezatu L, Hönes JM, Schütte J, Vassen L, Al-Matary YS, Patnana P, Zeller A, Heuser M, Thol F, Gabdoulline R, Olberding N, Frank D, Suslo M, Köster R, Lennartz K, Görgens A, Giebel B, Opalka B, Dührsen U, Khandanpour C. Growth factor independence 1b. A key player in the genesis and maintenance of acute myeloid leukaemia and myelodysplastic syndrome. Haematologica. 2018 Jan 11. pii: haematol.2017.167288. doi: 10.3324/haematol.2017.167288. [Epub ahead of print] PMID: 293261227.5
    2. Thorsten R. Doeppner, Mathias Bähr, Bernd Giebel and Dirk M. Hermann. Immunological and non-immunological effects of stem cell-derived extracellular vesicles on the ischaemic brain. Ther Adv Neurol Disord. 2018 Jul 26;11:1756286418789326. doi: 10.1177/1756286418789326. eCollection 2018 PMID: 300832313.5
    3. Wiklander OPB, Bostancioglu RB, Welsh JA, Zickler AM, Murke F, Corso G, Felldin U, Hagey DW, Evertsson B, Liang XM, Gustafsson MO, Mohammad DK, Wiek C, Hanenberg H, Bremer M, Gupta D, Björnstedt M, Giebel, B, Nordin JZ, Jones JC, El Andaloussi S, Görgens A. Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures. Front Immunol. 2018 Jun 13;9:1326. doi: 10.3389/fimmu.2018.01326. eCollection 2018. PMID: 299510644.7
    4. Ludwig AK, De Miroschedji K, Doeppner TR, Börger V, Ruesing J, Rebmann V, Durst S, Jansen S, Bremer M, Behrmann E, Singer BB, Jastrow H, Kuhlmann JD, El Magraoui F, Meyer HE, Hermann DM, Opalka B, Raunser S, Epple M, Horn PA, Giebel, B. Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales. J Extracell Vesicles. 2018 Oct 17 7(1):1528109. doi: 10.1080/20013078.2018.1528109. eCollection 2018. PMID: 3035700811.0
    5. E. M. Hummel, E. Hessas, S. Müller, T. Beiter, M. Fisch, A. Eibl, O. T. Wolf, B. Giebel, P. Platen, R. Kumsta and D. A. Moser. Cell-free DNA release under psychosocial and physical stress conditions. Translational Psychiatry (2018) 8:236. doi: 10.1038/s41398-018-0264-x. PMID: 303740185.1
    6. Ulrich H. Frey, Marina Klaassen, Crista Ochsenfarth, Florian Murke, Matthias Thielmann, Eva Kottenberg, Petra Kleinbongard, Stefanie Klenke, Andrea Engler, Gerd Heusch, Bernd Giebel, Jürgen Peters. Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro‐RNA signature in CABG patients. Acta Anaesthesiol Scand.2018;1–10.. doi: 10.1111/aas.13296. PMID: –2.2
    7. Clotilde Théry, Kenneth W Witwer, …, Bernd Giebel, …, Davide Zocco & Ewa K Zuba-Surma. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles, 7:1, 1535750, DOI: 10.1080/20013078.2018.1535750. PMID: –11.0
    ReferenceImpact Faktor
    1. Reiner AT, Witwer KW, van Balkom BWM, de Beer J, Brodie C, Corteling RL, Gabrielsson S, Gimona M, Ibrahim AG, de Kleijn D, Lai CP, Lötvall J, Del Portillo HA, Reischl IG, Riazifar M, Salomon C, Tahara H, Toh WS, Wauben MHM, Yang VK, Yang Y, Yeo RWY, Yin H, Giebel B, Rohde E, Lim SK. Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles. Stem Cells Transl Med. 2017 Aug;6(8):1730-1739. doi: 10.1002/sctm.17-0055. Epub 2017 Jul 17.4.0
    2. Giebel B. On the function and heterogeneity of extracellular vesicles. Ann Transl Med. 2017 Mar;5(6):150. doi: 10.21037/atm.2017.02.14. 
    3. EV-TRACK Consortium, Van Deun J, Mestdagh P, Agostinis P, Akay Ö, Anand S, Anckaert J, Martinez ZA, Baetens T, Beghein E, Bertier L, Berx G, Boere J, Boukouris S, Bremer M, Buschmann D, Byrd JB, Casert C, Cheng L, Cmoch A, Daveloose D, De Smedt E, Demirsoy S, Depoorter V, Dhondt B, Driedonks TA, Dudek A, Elsharawy A, Floris I, Foers AD, Gärtner K, Garg AD, Geeurickx E, Gettemans J, Ghazavi F, Giebel B, Kormelink TG, Hancock G, Helsmoortel H, Hill AF, Hyenne V, Kalra H, Kim D, Kowal J, Kraemer S, Leidinger P, Leonelli C, Liang Y, Lippens L, Liu S, Lo Cicero A, Martin S, Mathivanan S, Mathiyalagan P, Matusek T, Milani G, Monguió-Tortajada M, Mus LM, Muth DC, Németh A, Nolte-‚t Hoen EN, O’Driscoll L, Palmulli R, Pfaffl MW, Primdal-Bengtson B, Romano E, Rousseau Q, Sahoo S, Sampaio N, Samuel M, Scicluna B, Soen B, Steels A, Swinnen JV, Takatalo M, Thaminy S, Théry C, Tulkens J, Van Audenhove I, van der Grein S, Van Goethem A, van Herwijnen MJ, Van Niel G, Van Roy N, Van Vliet AR, Vandamme N, Vanhauwaert S, Vergauwen G, Verweij F, Wallaert A, Wauben M, Witwer KW, Zonneveld MI, De Wever O, Vandesompele J, Hendrix A. EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nat Methods. 2017 Feb 28;14(3):228-232. doi: 10.1038/nmeth.4185.25.1
    4. O’Driscoll L, Stoorvogel W, Théry C, Buzas E, Nazarenko I, Siljander P, Yáñez-Mó M, Fais S, Giebel B, Yliperttula M. European Network on Microvesicles and Exosomes in Health and Disease (ME-HaD). Eur J Pharm Sci. 2017 Feb 15;98:1-3. doi: 10.1016/j.ejps.2017.01.003.3.7
    5. Giebel B, Helmbrecht C. Methods to Analyze EVs. Methods Mol Biol. 2017;1545:1-20. 
    6. Börger V, Bremer M, Ferrer-Tur R, Gockeln L, Stambouli O, Becic A, Giebel B. Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents. Int J Mol Sci. 2017 Jul 6;18(7).3.2
    7. Bauer D, Alt M, Dirks M, Buch A, Heilingloh CS, Dittmer U, Giebel B, Görgens A, Palapys V, Kasper M, Eis-Hübinger AM, Sodeik B, Heiligenhaus A, Roggendorf M, Krawczyk A. A Therapeutic Antiviral Antibody Inhibits the Anterograde Directed Neuron-to-Cell Spread of Herpes Simplex Virus and Protects against Ocular Disease. Front Microbiol. 2017 Oct 31;8:2115. doi: 10.3389/fmicb.2017.02115. eCollection 2017. PMID: 291634074.0
    8. Hönes JM, Thivakaran A, Botezatu L, Patnana P, Castro SVDC, Al-Matary YS, Schütte J, Fischer KBI, Vassen L, Görgens A, Dührsen U, Giebel B, Khandanpour C. Enforced GFI1 expression impedes human and murine leukemic cell growth. Sci Rep. 2017 Nov 16;7(1):15720. doi: 10.1038/s41598-017-15866-9. PMID: 291470184.2
    9. Doeppner TR, Bähr M, Hermann DM, Giebel B. Concise Review: Extracellular Vesicles Overcoming Limitations of Cell Therapies in Ischemic Stroke. Stem Cells Transl Med. 2017 Nov;6(11):2044-2052. doi: 10.1002/sctm.17-0081. Epub 2017 Sep 23. Review. PMID: 289413174.0
    10. Corso G, Mäger I, Lee Y, Görgens A, Bultema J, Giebel B, Wood MJA, Nordin JZ, Andaloussi SE. Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography. Sci Rep. 2017 Sep 14;7(1):11561. doi: 10.1038/s41598-017-10646-x.4.2
    11. Drommelschmidt K, Serdar M, Bendix I, Herz J, Bertling F, Prager S, Keller M, Ludwig AK, Duhan V, Radtke S, de Miroschedji K, Horn PA, van de Looij Y, Giebel B, Felderhoff-Müser U. Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury. Brain Behav Immun. 2017;60:220-32 
    12. Giebel B, Kordelas L., Börger V. Clinical potential of mesenchymal stem/stromal cell-derived extracellular vesicles. Stem cell investigation. 2017 doi: 10.21037/sci.2017.09.06 PMID: 29167805
    ReferenceImpact Faktor
    1. Nardi Fda S, König L, Wagner B, Giebel B, Santos Manvailer LF, Rebmann V. Soluble monomers, dimers and HLA-G-expressing extracellular vesicles: the three dimensions of structural complexity to use HLA-G as a clinical biomarker. HLA. 2016 Sep; 88(3):77-86 
    2. Görgens A, Murke F, Kordelas L, Giebel B. Lost in Transplantation? Unexpected shift from multipotent to late lymphomyeloid hematopoietic stem and progenitor cells in patients 1 year after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2016 Aug; 51(8):1073-53.6
    3. Botezatu L, Michel LC, Helness A, Vadnais C, Hönes JM, Makishima H, Robert F, Vassen L, Aniththa Thivakaran1, Al-Matary Y, Lams RF, Schütte J, Giebel B, Görgens A, Heuser M, Medyouf H, Maciejewski J, Dührsen U, Möröy T,Khandanpour C. Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML. Exp. Hematol. 2016; 44(8):713-262.5
    4. Ophelders DRMG, Wolfs TGAM, Jellema RK, Zwanenburg A, Andriessen P, Delhaas T, Ludwig AK, Radtke S, Peters V, Janssen L, Giebel B and Kramer BW. Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia. Stem Cells Transl Med. 2016 Jun; 5(6): 754-635.7
    5. Hombach AA, Görgens A, Chmielewski M, Murke F, Kimpel J, Giebel B, Abken H. Superior therapeutic index in lymphoma therapy: CD30+ CD34+ hematopoietic stem cells resist a chimeric antigen receptor (CAR) T cell attack. Mol Ther. 2016 Aug; 24(8): 1423-346.2
    6. Nel I, Gauler TC, Bublitz K, Lazaridis L, Goergens A, Giebel B, Schuler M, Hoffmann AC. Circulating Tumor Cell Composition in Renal Cell Carcinoma. PLoS One. 2016; 11 (4): e01530183.5
    7. Fais S, O’Driscoll L, Borras FE, Buzas E, Camussi G, Cappello F, Carvalho J, Cordeiro da Silva A, Del Portillo H, El Andaloussi S, Ficko Trček T, Furlan R, Hendrix A, Gursel I, Kralj-Iglic V, Kaeffer B, Kosanovic M, Lekka ME, Lipps G, Logozzi M, Marcilla A, Sammar M, Llorente A, Nazarenko I, Oliveira C, Pocsfalvi G, Rajendran L, Raposo G, Rohde E, Siljander P, van Niel G, Vasconcelos MH, Yáñez-Mó M, Yliperttula ML, Zarovni N, Zavec AB and Giebel B. Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine. ACS Nano. 201612.9
    8. Hönes JM, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, Hergenhan SM, Thivakaran A, Schütte J, Al-Matary YS, Lams RF, Fraszscak J, Makishima H, Radivoyevitch T, Przychodzen B, da Conceição Castro SV, Görgens A, Giebel B, Klein-Hitpass L, Lennartz K, Heuser M, Thiede C, Ehninger G, Dührsen U, Maciejewski J, Möröy T, Khandanpour C. GFI1 as a novel prognostic and therapeutic factor for AML/MDS. Leukemia. 2016 Feb 5. doi: 10.1038/leu.2016.11.10.4
    9. Zeuner MT, Patel K, Denecke B, Giebel B, Widera D. Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles. J Transl Med. 2016 Feb.3.9
    10. Börger V, Bremer M, Görgens A, Giebel B. Mesenchymal stem/stromal cell-derived extracellular vesicles as a new approach in stem cell therapy. ISBT Sci Ser. 2016; 11 (1): 228–234 
    11. Radtke S, Görgens A, Liu B, Horn PA & Giebel B. Human mesenchymal and murine stromal cells support human lympho-myeloid progenitor expansion but not maintenance of multipotent haematopoietic stem and progenitors cells. Cell Cycle. 2016 Feb 16; 15(4): 540-55.0
    12. König L, Kasimir-Bauer S, Hoffmann O, Bittner AK, Wagner B, Manvailer LF, Schramm S, Bankfalvi A, Giebel B, Kimmig R, Horn PA, Rebmann V. The prognostic impact of soluble and vesicular HLA-G and its relationship to circulating tumor cells in neoadjuvant treated breast cancer patients. Hum Immunol. 2016; 77(9):791–992.3
    ReferenceImpact Faktor
    1. Denecke B, Horsch LD, Radtke S, Fischer JC, Horn PA, Giebel B. Human endothelial colony-forming cells expanded with an improved protocol are a useful endothelial cell source for scaffold-based tissue engineering.J Tissue Eng Regen Med. 2015; 9 (11): E84-975.2
    2. Murke F, Castro SVC, Giebel B, Görgens A. Concise Review: Asymmetric Cell Divisions in Stem Cell Biology. Symmetry. 2015; 7: 2025-20370.8
    3. Loeffek S, Ullrich N, Görgens A, Murke F, Eilebrecht M, Menne C, Giebel B, Schadendorf D, Singer BB, Helfrich I. CEACAM1-4L promotes anchorage-independent growth in melanoma. Front Oncol. 2015; 5: 234 
    4. Görgens A, Horn PA. From Basic Biology to Engineering and Clinical Translation of Stem Cells. Cellular Reprogramming. December 2015; 17 (6): 415-4181.8
    5. Börger V, Görgens A, Rohde E, Giebel B. Therapeutisches Potenzial von extrazellulären Vesikeln aus mesenchymalen Stamm- bzw. Stromazellen. Transfusionsmedizin. 2015; 5: 131–137 
    6. Doeppner TR, Herz J, Gorgens A, Schlechter J, Ludwig AK, Radtke S, de Miroschedji K, Horn PA, Giebel B and Hermann DM. Extracellular vesicles improve post-stroke neuroregeneration and prevent post-ischemic immunosuppression. Stem Cells Transl Med. 2015; 4 (10): 1131-435.7
    7. Görgens A, Giebel B. Wie unser Blut entsteht – neue Erkenntnisse zur Hämatopoese. BIOspektrum. 2015; 21 (3): 290-293 
    8. Yáñez-Mó M, Siljander PRM, Andreu Z, […], Giebel B, […], Vasconcelos MH, Wauben MHM, De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015; 4: 27066 
    9. Graffmann N, Brands J, Görgens A, Vitoriano da Conceição Castro S, Santourlidis S, Reckert A, Michele I, Ritz-Timme S, Fischer JC, Adjaye J, Kögler G, Giebel B, Uhrberg M. Age-related increase of EED expression in early hematopoietic progenitor cells is associated with global increase of the histone modification H3K27me3. Stem Cells Dev. 2015 May 11 [Epub]4.2
    10. Radtke S, Görgens A, Kordelas L, Schmidt M, Kimmig KR, Köninger A, Horn PA, Giebel B. CD133 allows elaborated discrimination and quantification of haematopoietic progenitor subsets in human haematopoietic stem cell transplants. Br. J. Haematol. 2015; 169 (6):868-785.0
    11. Krawczyk A, Dirks M, Kasper M, Buch A, Dittmer U, Giebel B, Wildschütz L, Busch M, Goergens A, Schneweis KE, Eis-Hübinger AM, Sodeik B, Heiligenhaus A, Roggendorf M, Bauer D. Prevention of Herpes Simplex Virus Induced Stromal Keratitis by a Glycoprotein B-Specific Monoclonal Antibody PLoS ONE. 2015; 10(1): e01168003.5
    12. Lener T, Gimona M, Aigner L, Börger V, Buzas E, Camussi G, Chaput N, Chatterjee D, Court FA, Del Portillo HA, O’Driscoll L, Fais S, Falcon-Perez JM, Felderhoff-Mueser U, Fraile L, Gho YS, Görgens A, Gupta RC, Hendrix A, Hermann DM, Hill AF, Hochberg F, Horn PA, de Kleijn D, Kordelas L, Kramer BW, Krämer-Albers EM, Laner-Plamberger S, Laitinen S, Leonardi T, Lorenowicz MJ, Lim SK, Lötvall J, Maguire CA, Marcilla A, Nazarenko I, Ochiya T, Patel T, Pedersen S, Pocsfalvi G, Pluchino S, Quesenberry P, Reischl IG, Rivera FJ, Sanzenbacher R, Schallmoser K, Slaper-Cortenbach I, Strunk D, Tonn T, Vader P, van Balkom BW, Wauben M, Andaloussi SE, Théry C, Rohde E, Giebel B. Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper J Extracell Vesicles. 2015 Dec 31;4:30087. doi: 10.3402/jev.v4.30087. eCollection 2015 
    13. Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-‚t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stępień E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics. 2015 Mar 15;31(6):933-9. doi: 10.1093/bioinformatics/btu741. Epub 2014 Nov 10. PMID: 25388151 
    ReferenceImpact Faktor
    1. Radtke, S., Giebel, B., Wagner, W., and Horn, P.A. Platelet lysates and their role in cell therapy. ISBT Science Series. 2014; 9(1): 193-7 
    2. Brandau S, Jakob M, Bruderek K, Bootz F, Giebel B, Radtke S, Mauel K, Jäger M, Flohé SB, Lang S. Mesenchymal stem cells augment the anti-bacterial activity of neutrophil granulocytes. PLoS One. 2014; 9(11): e1142013.5
    3. Müller CR, Mytilineos J, Ottinger H, Arnold R, Bader P, Beelen D, Bornhäuser M, Dreger P, Eiermann T, Einsele H, Faé I, Fischer G, Füssel M, Holler E, Holzberger G, Horn PA, Kröger N, Lindemann M, Seidl C, Spriewald B, Süsal C, Blasczyk R, Finke J. Deutscher Konsensus 2013 zur immungenetischen Spenderauswahl für die allogene Stammzelltransplantation. Transfusionsmedizin. 2014; 4: 190-6 
    4. Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, […], Giebel B, […], Zeidler R, Gho YS. EVpedia: A Community Web Portal for Extracellular Vesicles Research. Bioinformatics. 2014; 31 (6): 933-94.6
    5. Malyar NM, Radtke S, Malyar K, Arjumand J, Horn PA, Kröger K, Freisinger E, Reinecke H, Giebel B, Brock FE. Autologous Bone Marrow Mononuclear Cell Therapy Improves Symptoms in Patients with End-Stage Peripheral Arterial Disease and Reduces Inflammation Associated Parameters. Cytotherapy. 2014; 16(9): 1270-93.3
    6. Kordelas L, Rebmann V, Ludwig AK, Radtke S, Ruesing J, Doeppner TR, Epple M, Horn PA, Beelen DW, Giebel B. MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease. Leukemia. 2014; 28(4): 970-310.2
    7. Hemeda H, Giebel B, Wagner W. Evaluation of human platelet lysate versus fetal bovine serum for culture of mesenchymal stromal cells. Cytotherapy. 2014; 16(2): 170-803.3
    8. Görgens A, Ludwig AK, Möllmann M, Krawczyk A, Dürig J, Hanenberg H, Horn PA, Giebel B. Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages. Stem Cell Reports. 2014 Dec 9;3(6):1058-72. doi: 10.1016/j.stemcr.2014.09.016. Epub 2014 Oct 23. Erratum in: Stem Cell Reports. 2015 Jul 14;5(1):154-5. PMID: 25448068
    ReferenceImpact Faktor
    1. Görgens A, Radtke S, Horn PA, Giebel B. New Relationships of Human Hematopoietic Lineages Facilitate Detection of Multipotent Hematopoietic Stem and Progenitor Cells. Cell Cycle. 2013; 12(22): 3478-825.2
    2. Muturi HT, Dreesen, JD, Nilweski E, Jastrow H, Giebel B, Ergun S, Singer BB. Tumor and Endothelial Cell-Derived Microvesicles Carry Distinct CEACAMs and Influence T-Cell Behavior. PLOS One. 2013; 8(9): e746543.7
    3. Görgens A, Radtke S, Moellmann M, Cross M, Duerig J, Horn PA, Giebel B. Revision of the Human Hematopoietic Tree: Granulocyte Subtypes Derive from Distinct Hematopoietic Lineages. Cell Reports. 2013; 3(5): 1539-528.4
    4. Krawczyk A, Arndt MAE, Grosse-Hovestc L, Weichert W, Giebel B, Dittmer U, Hengel H, Jäger D, Schneweis KE, Eis-Hübingerg AM, Roggendorf M, Krauss J. Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody. Proc Natl Acad Sci USA. 2013; 110(17): 6760-59.7
    5. Schilling B, Sucker A, Griewank K, Zhao F, Weide B, Görgens A, Giebel B, Schadendorf D, Paschen A. Vemurafenib reverses immunosuppression by myeloid derived suppressor cells. Int J Cancer. 2013; 133(7): 1653-635.4
    ReferenceLink
    Gortner L, Felderhoff-Müser U, Monz D, Bieback K, Klüter H, Jellema R, Kramer BW, Keller M, Reiss I, Horn PA, Giebel B (2012)
    Regenerative therapies in neonatology: clinical perspectives
    Klin Pediatr    		pubmed
    Doeppner TR, Ewert TAS, Tönges L, Herz J, Zechariah A, ElAli S, Ludwig A-K, Giebel B, Nagel F, GPH, Weise J, Hermann DM, Bähr M (2012)  Transduction of Neural Precursor Cells with TAT-Hsp70 Chaperone: Therapeutic Potential Against Ischemic Stroke After Intrastriatal and Systemic Transplantation
    Stem Cells    		pubmed
    Goergens, A., Beckmann, J., Ludwig, A.-K., Möllmann, M., Dürig, J., Horn, P. A., Rajendran, L., & Giebel, B. (2012)  Lipid raft redistribution and morphological cell polarization are separable processes providing a basis for hematopoietic stem and progenitor cell migration
    International Journal of Biochemistry and Cell Biology (2012), doi:10.1016/j.biocel.2012.03.020     		pubmed
    Giebel B, Wodarz A (2012)  Notch signaling: numb makes the difference
    Curr Biol. 2012 Feb 21;22(4):R133-5     		pubmed
    ReferenceLink
    Ludwig AK, Giebel B (2011)  Exosomes: small vesicles participating in intercellular communication
    Int J Biochem Cell Biol. 2012 Jan;44(1):11-5     		 pubmed
    Radtke S, Horn PA (2011)  Cells, niche, fate: meeting report on the 6th International Meeting of the Stem Cell Network North Rhine Westphalia
    Cell Reprogram. 2011 Oct;13(5):381-4     		pubmed
    Sokolova V, Ludwig AK, Hornung S, Rotan O, Horn PA, Epple M, Giebel B (2011)  Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy Colloids Surf B Biointerfaces. 2011 Oct 1;87(1):146-50 pubmed
    ReferenceLink
    Hemeda H, Jakob M, Ludwig A, Giebel B, Lang S, Brandau S.  (2010)
    Interferon-gamma and Tumor Necrosis Factor-alpha Differentially Affect Cytokine Expression and Migration Properties of Mesenchymal Stem Cells
    Stem Cells Dev. 2010 May;19(5):693-706
         		Pubmed  [Summary]
    ReferenceLink
    Rajendran L, Beckmann J, Magenau A, Boneberg EM, Gaus K, Viola A, Giebel B, Illges H.  (2009)
    Flotillins are involved in the polarization of primitive and mature hematopoietic cells
    PLoS One e8290:    		Pubmed 
    [Summary]
    ReferenceLink
    Beier D, Röhrl S, Pillai DR, Schwarz S, Kunz-Schughart LA, Leukel P, Proescholdt M, Brawanski A, Bogdahn U, Trampe-Kieslich A, Giebel B, Wischhusen J, Reifenberger G, Hau P  (2008)
    Temozolomide preferentially depletes cancer stem cells in glioblastoma
    Cancer Res. 68(14): 5706-15
         		Pubmed [Summary]
    Giebel B, Punzel M  (2008)
    Lineage development of hematopoietic stem and progenitor cells.
    Biol Chem 389(7): 813-24
         		Pubmed
    [Summary]
    Giebel B, Bruns I.  (2008)
    Self-renewal versus differentiation in hematopoietic stem and progenitor cells: a focus on asymmetric cell divisions.
    Curr Stem Cell Res Ther 3(1): 9-16
         		Pubmed
    [Summary]
    Giebel B.   (2008)
    Cell polarity and asymmetric cell division within human hematopoietic stem and progenitor cells.
    Cells Tissues Organs 188(1-2): 116-26    		Pubmed
    [Summary]
    ReferenceLink
    Giebel B, Beckmann J.  (2007)
    Asymmetric cell divisions of human hematopoietic stem and progenitor cells meet endosomes.
    Cell Cycle 6(18): 2201-4
         		Pubmed 
    [Summary]
    Feldhahn N, Henke N, Melchior K, Duy C, Soh BN, Klein F, von Levetzow G, Giebel B, Li A, Hofmann WK, Jumaa H, Müschen M.  (2007)
    Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells.
    J Exp Med 204(5): 1157-66
         		Pubmed [Summary]
    Beckmann J, Scheitza S, Wernet P, Fischer JC, Giebel B. (2007)
    Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins.
    Blood 109(12): 5494-501    		Pubmed
    [Summary]
    ReferenceLink
    von Levetzow G, Spanholtz J, Beckmann J, Fischer J, Kögler G, Wernet P, Punzel M, Giebel B. (2006)
    Nucleofection, an efficient nonviral method to transfer genes into human hematopoietic stem and progenitor cells.
    Stem Cells Dev 15(2): 278-85
         		Pubmed  [Summary]
    Giebel B, Wodarz A.  (2006)
    Tumor suppressors: control of signaling by endocytosis.
    Curr Biol 16(3): R91-2
         		Pubmed 
    [Summary]
    Bracker TU, Giebel B, Spanholtz J, Sorg UR, Klein-Hitpass L, Moritz T, Thomale J.  (2006)
    Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis.
    Stem Cells 24(3): 722-30    		Pubmed
    [Summary]
    ReferenceLink
    Giebel B, Corbeil D, Beckmann J, Höhn J, Freund D, Giesen K, Fischer J, Kögler G, Wernet P.  (2004)
    Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells.
    104(8 Blood 104(8: 2332-8
         		Pubmed 
    [Summary]
    Schneider EM, Torlakovic E, Stühler A, Diehl V, Tesch H, Giebel B.  (2004)The early transcription factor GATA-2 is expressed in classical Hodgkin\\\’s lymphoma.
    J Pathol 204(5): 538-45
         		Pubmed
    [Summary]

    Kontakt

    Univ.-Prof. Dr. rer. nat. Bernd Giebel
    University Hospital Essen
    Insitute for Transfusion Medicine
    Hufelandstraße 55
    45122 Essen
    Robert Koch Haus III
    Tel: +49 (0) 201-723-4204
    Email: bernd.giebel@uk-essen.de